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Separation of suspended particles by arrays of obstacles in microfluidic devices

机译:微流体中障碍物阵列分离悬浮颗粒   设备

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摘要

The stochastic transport of suspended particles through a periodic pattern ofobstacles in microfluidic devices is investigated by means of the Fokker-Planckequation. Asymmetric arrays of obstacles have been shown to induce thecontinuous separation of DNA molecules of different length. The analysispresented here of the asymptotic distribution of particles in a unit cell ofthese systems shows that separation is only possible in the presence of adriving force with a non-vanishing normal component at the surface of the solidobstacles. In addition, vector separation, in which different species move, inaverage, in different directions within the device, is driven by differences onthe force acting on the various particles and not by differences in thediffusion coefficient. Monte-Carlo simulations performed for differentparticles and force fields agree with the numerical solutions of theFokker-Planck equation in the periodic system.
机译:通过福克-普朗克方程研究了悬浮颗粒通过微流体装置中障碍物的周期性分布的随机迁移。障碍物的不对称阵列已显示出可诱导不同长度DNA分子的连续分离。此处对这些系统的晶胞中的渐近分布进行的分析表明,只有在固体障碍物表面无正常成分的驱动力存在的情况下,才可能进行分离。另外,矢量分离是由作用在各种颗粒上的力的差异而不是由扩散系数的差异来驱动的,其中,不同的物种平均地沿设备内的不同方向移动。针对不同粒子和力场进行的蒙特卡洛模拟与周期系统中Fokker-Planck方程的数值解一致。

著录项

  • 作者

    Li, Zhigang; Drazer, German;

  • 作者单位
  • 年度 2006
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  • 原文格式 PDF
  • 正文语种 {"code":"en","name":"English","id":9}
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